Anthrax Lethal Factor
Novel small-molecule inhibitors of anthrax lethal factor identified by high-throughput screening.
Schepetkin IA, Khlebnikov AI, Kirpotina LN, Quinn MT.
J Med Chem. 2006 Aug 24;49(17):5232-44.
Coxiella Burnetii
Inhibition of the human neutrophil NADPH oxidase by Coxiella burnetii.
Siemsen DW, Kirpotina LN, Jutila MA, Quinn MT.
Microbes Infect. 2009 May-Jun;11(6-7):671-9. doi: 10.1016/j.micinf.2009.04.005.
Staphylococcus Aureus
Sublytic concentrations of Staphylococcus aureus Panton-Valentine leukocidin alter human PMN gene expression and enhance bactericidal capacity.
Graves SF, Kobayashi SD, Braughton KR, Whitney AR, Sturdevant DE, Rasmussen DL, Kirpotina LN, Quinn MT, DeLeo FR.
J Leukoc Biol. 2012 Aug;92(2):361-74. doi: 10.1189/jlb.1111575.
C5a Receptor
Molecular analysis of the bovine anaphylatoxin C5a receptor.
Nemali S, Siemsen DW, Nelson LK, Bunger PL, Faulkner CL, Rainard P, Gauss KA, Jutila MA, Quinn MT.
J Leukoc Biol. 2008 Aug;84(2):537-49. doi: 10.1189/jlb.0208142.
TNF-alfa
Computational structure-activity relationship analysis of non-peptide inducers of macrophage tumor necrosis factor-alpha production.
Khlebnikov AI, Schepetkin IA, Kirpotina LN, Quinn MT.
Bioorg Med Chem. 2008 Oct 15;16(20):9302-12. doi: 10.1016/j.bmc.2008.08.078.
Identification of novel formyl peptide receptor-like 1 agonists that induce macrophage tumor necrosis factor alpha production.
Schepetkin IA, Kirpotina LN, Tian J, Khlebnikov AI, Ye RD, Quinn MT.
Mol Pharmacol. 2008 Aug;74(2):392-402. doi: 10.1124/mol.108.046946.
CXCR1/2
Boronic acid-containing aminopyridine- and aminopyrimidinecarboxamide CXCR1/2 antagonists: Optimization of aqueous solubility and oral bioavailability.
Schuler AD, Engles CA, Maeda DY, Quinn MT, Kirpotina LN, Wicomb WN, Mason SN, Auten RL, Zebala JA.
Bioorg Med Chem Lett. 2015 Sep 15;25(18):3793-7. doi: 10.1016/j.bmcl.2015.07.090.
Boronic acid-containing CXCR1/2 antagonists: Optimization of metabolic stability, in vivo evaluation, and a proposed receptor binding model.
Maeda DY, Peck AM, Schuler AD, Quinn MT, Kirpotina LN, Wicomb WN, Auten RL, Gundla R, Zebala JA.
Bioorg Med Chem Lett. 2015 Jun 1;25(11):2280-4. doi: 10.1016/j.bmcl.2015.04.041.
Discovery of 2-[5-(4-Fluorophenylcarbamoyl)pyridin-2-ylsulfanylmethyl]phenylboronic Acid (SX-517): Noncompetitive Boronic Acid Antagonist of CXCR1 and CXCR2.
Maeda DY, Peck AM, Schuler AD, Quinn MT, Kirpotina LN, Wicomb WN, Fan GH, Zebala JA.
J Med Chem. 2014 Oct 23;57(20):8378-97. doi: 10.1021/jm500827t.
Nicotinamide glycolates antagonize CXCR2 activity through an intracellular mechanism.
Maeda DY, Quinn MT, Schepetkin IA, Kirpotina LN, Zebala JA.
J Pharmacol Exp Ther. 2010 Jan;332(1):145-52. doi: 10.1124/jpet.109.159020.
Quantitative structure-activity relationships for small non-peptide antagonists of CXCR2: indirect 3D approach using the frontal polygon method.
Khlebnikov AI, Schepetkin IA, Quinn MT.
Bioorg Med Chem. 2006 Jan 15;14(2):352-65.
Other
Memorial: Gary Michael Bokoch, 1954-2010.
Quinn MT, DeLeo FR, Nauseef WM.
J Leukoc Biol. 2010 Apr;87(4):535-6. doi: 10.1189/jlb.0210081. No abstract available.
Novel small-molecule inhibitors of anthrax lethal factor identified by high-throughput screening.
Schepetkin IA, Khlebnikov AI, Kirpotina LN, Quinn MT.
J Med Chem. 2006 Aug 24;49(17):5232-44.
Coxiella Burnetii
Inhibition of the human neutrophil NADPH oxidase by Coxiella burnetii.
Siemsen DW, Kirpotina LN, Jutila MA, Quinn MT.
Microbes Infect. 2009 May-Jun;11(6-7):671-9. doi: 10.1016/j.micinf.2009.04.005.
Staphylococcus Aureus
Sublytic concentrations of Staphylococcus aureus Panton-Valentine leukocidin alter human PMN gene expression and enhance bactericidal capacity.
Graves SF, Kobayashi SD, Braughton KR, Whitney AR, Sturdevant DE, Rasmussen DL, Kirpotina LN, Quinn MT, DeLeo FR.
J Leukoc Biol. 2012 Aug;92(2):361-74. doi: 10.1189/jlb.1111575.
C5a Receptor
Molecular analysis of the bovine anaphylatoxin C5a receptor.
Nemali S, Siemsen DW, Nelson LK, Bunger PL, Faulkner CL, Rainard P, Gauss KA, Jutila MA, Quinn MT.
J Leukoc Biol. 2008 Aug;84(2):537-49. doi: 10.1189/jlb.0208142.
TNF-alfa
Computational structure-activity relationship analysis of non-peptide inducers of macrophage tumor necrosis factor-alpha production.
Khlebnikov AI, Schepetkin IA, Kirpotina LN, Quinn MT.
Bioorg Med Chem. 2008 Oct 15;16(20):9302-12. doi: 10.1016/j.bmc.2008.08.078.
Identification of novel formyl peptide receptor-like 1 agonists that induce macrophage tumor necrosis factor alpha production.
Schepetkin IA, Kirpotina LN, Tian J, Khlebnikov AI, Ye RD, Quinn MT.
Mol Pharmacol. 2008 Aug;74(2):392-402. doi: 10.1124/mol.108.046946.
CXCR1/2
Boronic acid-containing aminopyridine- and aminopyrimidinecarboxamide CXCR1/2 antagonists: Optimization of aqueous solubility and oral bioavailability.
Schuler AD, Engles CA, Maeda DY, Quinn MT, Kirpotina LN, Wicomb WN, Mason SN, Auten RL, Zebala JA.
Bioorg Med Chem Lett. 2015 Sep 15;25(18):3793-7. doi: 10.1016/j.bmcl.2015.07.090.
Boronic acid-containing CXCR1/2 antagonists: Optimization of metabolic stability, in vivo evaluation, and a proposed receptor binding model.
Maeda DY, Peck AM, Schuler AD, Quinn MT, Kirpotina LN, Wicomb WN, Auten RL, Gundla R, Zebala JA.
Bioorg Med Chem Lett. 2015 Jun 1;25(11):2280-4. doi: 10.1016/j.bmcl.2015.04.041.
Discovery of 2-[5-(4-Fluorophenylcarbamoyl)pyridin-2-ylsulfanylmethyl]phenylboronic Acid (SX-517): Noncompetitive Boronic Acid Antagonist of CXCR1 and CXCR2.
Maeda DY, Peck AM, Schuler AD, Quinn MT, Kirpotina LN, Wicomb WN, Fan GH, Zebala JA.
J Med Chem. 2014 Oct 23;57(20):8378-97. doi: 10.1021/jm500827t.
Nicotinamide glycolates antagonize CXCR2 activity through an intracellular mechanism.
Maeda DY, Quinn MT, Schepetkin IA, Kirpotina LN, Zebala JA.
J Pharmacol Exp Ther. 2010 Jan;332(1):145-52. doi: 10.1124/jpet.109.159020.
Quantitative structure-activity relationships for small non-peptide antagonists of CXCR2: indirect 3D approach using the frontal polygon method.
Khlebnikov AI, Schepetkin IA, Quinn MT.
Bioorg Med Chem. 2006 Jan 15;14(2):352-65.
Other
Memorial: Gary Michael Bokoch, 1954-2010.
Quinn MT, DeLeo FR, Nauseef WM.
J Leukoc Biol. 2010 Apr;87(4):535-6. doi: 10.1189/jlb.0210081. No abstract available.