Molecular docking of IQ-1S and Rabeximod in the JNK1 binding site
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A novel dual NO-donating oxime and c-Jun N-terminal kinase inhibitor protects against cerebral ischemia-reperfusion injury in mice.
Atochin DN, Schepetkin IA, Khlebnikov AI, Seledtsov VI, Swanson H, Quinn MT, Huang PL. Neurosci Lett. 2016 Apr 8;618:45-9. doi: 10.1016/j.neulet.2016.02.033. Anti-Inflammatory Effects and Joint Protection in Collagen-Induced Arthritis after Treatment with IQ-1S, a Selective c-Jun N-Terminal Kinase Inhibitor. Schepetkin IA, Kirpotina LN, Hammaker D, Kochetkova I, Khlebnikov AI, Lyakhov SA, Firestein GS, Quinn MT. J Pharmacol Exp Ther. 2015 Jun;353(3):505-16. doi: 10.1124/jpet.114.220251. Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors. Schepetkin IA, Kirpotina LN, Khlebnikov AI, Hanks TS, Kochetkova I, Pascual DW, Jutila MA, Quinn MT. Mol Pharmacol. 2012 Jun;81(6):832-45. doi: 10.1124/mol.111.077446. |