Histological analyses showing the difference in levels and patterns of inflammatory cell infiltration between the MGAS5005 and ΔsseMGAS5005 infections
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Group A Streptococcus secreted esterase hydrolyzes platelet-activating factor to impede neutrophil recruitment and facilitate innate immune evasion.
Liu M, Zhu H, Li J, Garcia CC, Feng W, Kirpotina LN, Hilmer J, Tavares LP, Layton AW, Quinn MT, Bothner B, Teixeira MM, Lei B. PLoS Pathog. 2012;8(4):e1002624. doi: 10.1371/journal.ppat.1002624. Defects in ex vivo and in vivo growth and sensitivity to osmotic stress of group A Streptococcus caused by interruption of response regulator gene vicR. Liu M, Hanks TS, Zhang J, McClure MJ, Siemsen DW, Elser JL, Quinn MT, Lei B. Microbiology. 2006 Apr;152(Pt 4):967-78. |